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Publications III (2011-present)  -  Publications II (2001-2010)   -   Publications I (1991-2000)

Bender, C., Christen, S., Scholich, K., Bayer, M., Pfeilschifter, J.M., Hintermann, E., Christen, U. (2017)

Islet-expressed CXCL10 promotes autoimmune destruction of islet iso-grafts in mice with type 1 diabetes.

Diabetes (in press)


Hintermann, E., Bayer, M., Ehser, J., Aurrand-Lions, M., Pfeilschifter, J.M., Imhof, BA., Christen, U. (2016)

Murine junctional adhesion molecules JAM-B and JAM-C mediate endothelial - and stellate cell interactions during hepatic fibrosis.

Cell. Adh. Migr.10: 419-433


Müller, P., Messmer, M., Bayer, M., Pfeilschifter, J.M., Hintermann, E., Christen, U. (2016)

Non-alcoholic fatty liver disease (NAFLD) potentiates autoimmune hepatitis in the CYP2D6 mouse model.

J. Autoimmun 69: 51-58


Berner, A., Bachmann, M., Bender. C., Pfeilschifter, J.M., Christen, U., Mühl, H., (2016)

Though active in RINm5F insulinoma cells and cultured pancreatic islets, recombinant IL-22 fails to modulate cytotoxicity and disease in a protocol of streptozotocin-induced experimental diabetes.

Front. Phramacol. 6: 317.


Lasch, S., Müller, P., Bayer, M., Pfeilschifter, J.M., Luster, A.D., Hintermann, E., and Christen, U. (2015)

Anti-CD3/anti-CXCL10 antibody combination therapy induces a persistent remission of type 1 diabetes in two mouse models.

Diabetes 64: 4198-4211


Shaabani, N., Khaimar, V., Duhan, V., Zhou, F., Tur, R.F., Häussinger, D., Recher, M., Tumanov, A.V., Hardt, C., Pinschewer, D., Christen, U., Lang, P.A., Honke, N., and Lang, K.S. (2015)

Two separate mechanisms of enforced viral replication balance innate and adaptive immune activation.

J. Autoimmun. 67: 82-89


Christen, U. (2015)

An update on animal models for autoimmune hepatitis: Are we there yet?

Curr. Pharm. Des. 21: 2391-2400.


Christen, U. (2015)

CXCR3 ligands.

In: Encyclobedia of Inflammatory Diseases, Springer Verlag, Germany (ed: Michael Parnham).


Hintermann, E., Bayer. M., Pfeilschifter, J.M., Deak, F., Kiss, I., Paulsson, M., and Christen, U. (2015)

Upregulation of matrilin-2 expression in murine hepatic stellate cells during liver injury has no effect on fibrosis formation and resolution.

Liver Int. 35: 1265-1273.


Christen, U. (2014)

Pathogen infection and autoimmunity.

Int. Rev. Immunol 33: 261-265.


Christen, U. and Hintermann, E (2014)

Pathogen infection and autoimmune hepatitis.

Int. Rev. Immunol. 33: 296-313.


Bender, C., Schlosser, M., Christen, U., Ziegler, G.A., and Achenbach, P. (2014)

GAD autoantibody affinity in schoolchildren from the general population.

Diabetologia 57: 1911-1918.


Christen U. (2013)

Molecular mimicry.

In: Autoantibodies (3rd edition), Elsevier, Amsterdam, The Netherlands (eds. Yehuda Shoenfeld, Pier-Luigi Meroni, M. Eric Gershwin).


Christen U., and von Herrath M.G. (2013)

Virus-induced mouse models for type 1 diabetes.

In: Diabetes and Viruses, Springer Verlag, Germany (eds: Keith Taylor, Heikki Hyöty, Antonio Toniolo and Arie Zuckerman).


Hintermann, E., Ehser, J., Bayer, M., Pfeilschifter, J.M., and Christen, U. (2013)

Induction of hepatic fibrosis by an adenovirus encoding the human liver autoantigen Cytochrome P450 2D6.

J. Autoimmun. 44: 49-60.


Coppieters, KT., Amirian, N., Pagni, P.P., Jones, C.B., Wiberg, A., Lasch, S., Hintermann, E., Christen, U,. and von Herrath, M.G. (2013)

Functional redundancy of CXCR3/CXCL10 signalling in the recruitment of diabetogenic CTL to pancreatic islets in a virally induced autoimmune diabetes model.

Diabetes 62: 2492-2499.


Ehser, J., Holdener, M., Christen, S., Bayer, M., Pfeilschifter, J.M., Hintermann, E., Bogdanos, D., and Christen, U. (2013)

Molecular mimicry rather than identity breaks T-cell tolerance in the CYP2D6 mouse model for human autoimmune hepatitis.

J. Autoimmun. 42: 39-49.


Christen U. (2013)

The role of antibodies in autoimmune hepatitis type 2: Diagnosc markers, pathogenic triggers or therapeutic agents?

Future Medicine: Immunotherapy 5: 247-256.


Christen, S., Christen, S., Coppieters, K., Rose, K., Holdener, M., Bayer, M., Pfeilschifter, J.M., Hintermann, E., von Herrath, M.G., Aurrand-Lions, M., Imhof, B.A., and Christen, U. (2013)

Blockade but not overexpression of the junctional adhesion molecule C influences virus-induced type 1 diabetes in mice.

PLOS ONE 8: e54675.


Rose, K., Penna-Martinez, M., Klahold, E., Kärger, D., Shoghi, F., Kahles, H., Bayer, M., Hintermann, E., Pfeilschifter, J.M., Badenhoop, K., Ramos-Lopez, E., and Christen U. (2013)

Influence of the vitamin D plasma level and vitamin D related genetic polymorphisms on the immune status of patients with type 1 diabetes: A pilot study.

Clin. Exp. Immunol. 171: 171-185.


Christen U, Bender C, von Herrath MG. (2012)

Infection as a cause of type 1 diabetes?

Curr Opin Rheumatol. 24:417-23.


Hintermann E, Ehser J, and Christen U. (2012)

The CYP2D6 animal model: how to induce autoimmune hepatitis in mice.

J. Vis. Exp. 60: e3644 1-7.

Link to video paper:


Hintermann, E., Holdener, M., Bayer, M., Loges, S., Pfeilschifter, J.M., Granier, C., Manns, M.P., and Christen, U. (2011)

Epitope spreading of the anti-CYP2D6 antibody response in patiemts with autoimmune hepatitis and in the CYP2D6 mouse model.

J. Autoimmun. 37:242-253.

Christen, S., Holdener, M., Beerli, C., Thoma, G., Bayer, M., Pfeilschifter, J.M., Hintermann, E., Zerwes, H.G. and Christen, U. (2011)

Small molecule CXCR3 antagonist NIBR2130 has only a limited impact on type 1 diabetes in a virus-induced mouse model.

Clin. Exp. Immunol. 165:318-328.


Christen, U. and von Herrath, M.G. (2011)

Do virus infections protect from or enhance type 1 diabetes and how can we tell the difference?

Cell. Mol. Immunol. 8: 193-198.