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Publications III (2011-present)   -   Publications II (2001-2010)  -  Publications I (1991-2000)



Hintermann, E., Bayer, M., Pfeilschifter, J.M., Luster, A.D., and Christen, U. (2010)

CXCL10 promotes liver fibrosis ny prevention of NK cell mediated hepatic stellate cell inactivation.

J. Autoimmun. 35: 424-435



Christen, U. (2010)

Enterovirus infection of human beta-cells activates dendritic cells and triggers antiviral responses: are enteroviruses convicted now?

Diabetes 59: 1126-1128



Bachmann, M., Horn, K., Rudloff, I., Goren, I., Holdener, M., Christen, U., Darsow, N., Hunfeld, K.P., Koehl, U., Kind, P., Pfeilschifter, J., Kraiczy, P., and Mühl, H. (2010)

Early production of IL-22 but not IL-17 by peripheral blood mononuclear cells exposed to live Borrelia burgdorferi: the role of monocytes and interleukin-1.

PLoS Pathog. 14: 6(10)



Christen, U., Holdener, M., and Hintermann, E. (2010)

Cytochrome P450 2D6 as a model antigen.

In: Immunology and Liver Disease - Proceedings of the Falk Symposium

Dig. Dis. 28: 80-85



Christen, U., Hintermann, E., Holdener, M., and von Herrath, M.G. (2010)

Viral triggers for autoimmunity: Is the glass of molecular mimicry half full or half empty?

J. Autoimmun. 34: 38-44



Horwitz, M., Efrat, S., Christen, U., von Herrath, M.G., and Oldstone, M.B.A. (2009)

Adenovirus E3 MHC inhibitory genes but not TNF/Fas apoptotic inhibitory genes expressed in beta-cells prevent autoimmune diabetes.

Proc. Nat. Acad. Sci. 106: 19450-19454.



Christen, U., Hintermann, E., and Jaeckel, E. (2009)

New animal models for autoimmune hepatitis.

Semin. Liver Dis. 29: 262-272



Holdener, M., Hintermann, E., Bayer, M., Rhode, A., Rodrigo, E., Hintereder, G., Johnson, E.F., Gonzalez, F.J., Pfeilschifter, J., Manns, M.P., von Herrath, M.G., and Christen, U. (2008)

Breaking tolerance to the natural human liver autoantigen Cytochrome P450 2D6 by virus infection.

J. Exp. Med. 205: 1409-1422


Bogdanos, D.P.B. and Christen, U. (2008)

Autoimmune Hepatitis: An Update on Current Animal Models.

The Open Pathology Journal 2: 39-45


Lastres-Becker, I., Brodesser, S., Lütjohann, D., Azizov, M., Buchmann, J., Hintermann, E., Sandhoff, K., Schürmann, A., Nowock, J., Auburger, G. (2008)

Insulin receptor and lipid metabolism pathology in ataxin-2 knock-out mice.

Hum Mol Genet. 15: 1465-1481.

Fink K, Zellweger R, Weber J, Manjarrez-Orduno N, Holdener M, Senn BM, Hengartner H, Zinkernagel RM, Macpherson AJ. (2008)

Long-term maternal imprinting of the specific B cell repertoire by maternal antibodies.

Eur J Immunol. 38: 90-101.

Hintermann, E. and Christen, U. (2007)

Viral infection – a cure for type 1 diabetes?

Current Medicinal Chemistry 14: 2048-2052.

Christen, U., Holdener, M. and Hintermann, E., (2007)

Animal Models for Autoimmune Hepatitis.

Autoimmunity Reviews 6: 306-311.

Christen, U. (2007)

Chemokines as drug targets in type 1 diabetes.

Endocr Metab Immune Disord Drug Targets 7: 7-12.


Goren, I., Muller, E., Schiefelbein, D., Christen, U., Pfeilschifter, J., Muehl, H. and Frank, S. (2007)

Systemic anti-TNFalpha treatment restores diabetes-impaired skin repair in ob/ob mice by inactivation of macrophages.

J. Invest. Dermatol. 127: 2259-2267.


Martinic, M.M., Juedes, A.E., Bresson, D., Homann, D., Skak, K., Huber, C., Ling, E., Ejrnaes, M., Wolfe, T., Togher, L., Christen, U., and von Herrath, M.G. (2007)

Minimal impact of a de-novo expressed b-cell autoantigen on spontaneous diabetes development in NOD mice.

Diabetes 56: 1059-1068.


Ejrneas, M. von Herrath, M.G. and Christen, U. (2006)

Cure of chronic viral infection and virus-induced type 1 diabetes by neutralizing antibodies.

Clin. Develop. Immunol. 13: 67-77.


Fink K, Lang KS, Manjarrez-Orduno N, Junt T, Senn BM, Holdener M, Akira S, Zinkernagel RM, Hengartner H. (2006)

Early type I interferon-mediated signals on B cells specifically enhance antiviral humoral responses.

Eur J Immunol. 36(8):2094-105.


von Allmen N, Christen S, Forster U, Gottstein B, Welle M, Muller N. (2006)

Acute trichinellosis increases susceptibility to Giardia lamblia infection in the mouse model.

Parasitology 133: 139-49.


Fujinami, R.S., von Herrath, M.G., Christen, U. and Whitton, J.L. (2006)

Molecular mimicry, bystander activation, or viral persistence: infections and autoimmune disease.

Clin Microbiol Rev.19: 80-94.


Barral, A.M., Thomas, H.E., Ling, E.M., Darwiche, R., Rodrigo, E., Christen, U., Ejrneas, M., Wolfe, T., Kay, T.W., and von Herrath, M.G. (2006)

SOCS-1 protects from virally-induced CD8 T cell mediated type 1 diabetes.

J. Autoimm. 27: 166-173.


Rhode, A., Pauza, M., Barral, A., Oldstone, M.B.A., von Herrath, M.G., and Christen, U. (2005)

Islet-specific expression of IP-10 (CXCL10) targets lymphocytes to the pancreas and accelerates type 1 diabetes.

J. Immunol. 175: 3516-3524.


Hintermann, E., Yang, N., O’Sullivan, D., Higgins, J.M., and Quaranta, V. (2005)

Integrin alpha6beta4/erbB2 complex inhibits haptotaxis by upregulating E-cadherin cell-cell junctions in keratinocytes.

J. Biol. Chem. 280: 8004-8015.


Christen, U. (2005)

Meeting report: Vaccination, infection and autoimmunity: Myth and Reality. VIAMR 2005, Lausanne, Switzerland.

Investigational Drug Database (IDDB) Published online: www.iddb.com RF635148


Christen, U. and von Herrath, M.G. (2005)

Infection and Autoimmunity.

J. Immunol. 174 (12): 7481-7486.


Christen, U. and von Herrath, M.G. (2005)

Viruses as initiators, accelerators or terminators of autoimmunity? – A question of time and location of infection.

In: Autoimmune Liver Disease – Proceedings of the Falk Symposium 142


Ejrnaes, M., Videbaek, N., Christen, U., Michelsen, B., and von Herrath, M. G. (2005)

Different Diabetogenic Potential of Autoaggressive CD8+ Clones Associated with CXCL10 Production but not Cytokine Expression, Cytolytic Activity or Homing Characteristics.

J. Immunol. 174: 2746-2755.


Christen, U., Edelmann, K., McGavern, D. B., Wolfe, T., Rodrigo, E., Coon, B., Oldstone, M. B. A. and von Herrath, M. G. (2004)

A viral epitope that mimics a self-antigen can accelerate but not initiate disease.

J. Clin. Invest. 114: 1290-1298.


Christen, U. and von Herrath, M.G. (2004)

Initiating Autoimmunity.

Curr. Opin. Immunol 16 (6) 759-767.


Madakamutil, L. T., Christen, U., Lena, C. J., Wang-Zhu, Y., Attinger, A., Sundarrajan, M., Ellmeier, W., von Herrath, M. G., Jensen, P., Littman, D. R. and Cheroutre, H. (2004)

CD8aa-mediated survival and differentiation of CD8 memory T cell precursors.

Science 304: 590-593.


Christen, U., Wolfe, T., Rodrigo, E., Chervonsky, A., Flavell, R. A., and von Herrath, M. G. (2004)

Virally induced inflammation triggers fratricide of FAS-L expressing b-cells.

Diabetes 53: 591-596.


Christen, U. and von Herrath, M.G. (2004)

IP-10 and Type 1 Diabetes: A Question of Time and Location.

Autoimmunity 39 (4): 273-282.



Christen, U. and von Herrath, M. G. (2004)

Manipulating the Type 1 vs. Type 2 Balance in Type 1 Diabetes.

Immunol Res. 30: 309-325.


Christen, U., Benke, D., Wolfe, T., Rodrigo, E., Rhode, A., Hughes, A. C., Oldstone, M. B. A., and von Herrath, M. G. (2004)

Cure of prediabetic mice by viral infections involves lymphocyte recruitment along an IP-10 gradient.

J. Clin. Invest.113: 74-84.

Christen, U., Juedes, A., Homann, D., and von Herrath., M. G. (2004)

Virally induced inflammation and therapeutic avenues in type 1 diabetes.

Endocrinol Metab Clin North Am. 33:45-58.


Hintermann, E., and Quaranta, V. (2004)

Epithelial cell motility on laminin-5: regulation by matrix assembly, proteolysis, integrins and erbB receptors.

Matrix Biol. 23(2): 75-85.


Christen, U. and von Herrath, M. G. (2004)

Induction, Acceleration or Prevention of Autoimmunity by Molecular Mimicry.

Mol. Immunol. 40: 1113-1120.


Christen, U., Wolfe, T., Moehrle, U., Hughes, A. C., Rodrigo, E., Green, A., Flavell, R. A., and von Herrath, M. G. (2001)

A Dual Role for TNFa in Type 1 Diabetes: Islet Specific Expression Abrogates the Ongoing Autoimmune Process when Induced Late but not Early During Pathogenesis.

J. Immunol. 166: 7023-7032.



Hintermann, E., Dorfleutner, A., Tarui, T., Takada, Y., and Ruf, W. (2004)

Cross-talk of integrin alpha3beta1 and tissue factor in cell migration.

Mol. Biol. Cell. 15(10): 4416-4425.


Janssen, E. M., Lemmens, E. E., Wolfe, T., Christen, U., von Herrath, M. G., and Schoenberger, S. P. (2003)

CD4+ T cells are required for secondary expansion and memory in CD8+ T lymphocytes.

Nature 421: 852-856.


Schenk, S., Hintermann, E., Bilban, M., Koshikawa, N., Hojilla, C., Khokha, R., and Quaranta, V. (2003)

Binding to EGF receptor of a laminin-5 EGF-like fragment liberated during MMP-dependent mammary gland involution.

J. Cell Biol. 161(1): 197-209.

Christen U. and von Herrath, M. G. (2003) Cytokines and chemokines in virus-induced autoimmunity. Adv. Exp. Med. Biol. 520:203-220.


Bilban, M., Ghaffari-Tabrizi, N., Hintermann, E., Bauer, S., Molzer, S., Zoratti, C., Malli, R., Sharabi, A., Hiden, U., Graier, W., Knoefler, M., Andreae, F., Wagner, O., Quaranta, V., and Desoye, G. (2003)

Kisspeptin-10, a KiSS-1/metastin-derived decapeptide, is a physiologic invasion inhibitor of primary human trophoblasts.

J. Cell Sci. 117(8): 1319-1328.


Christen, U., and von Herrath, M. G. (2002)

Transgenic animals models for type 1 diabetes: Linking a tetracycline inducible promotor with a virus-inducible mouse model.

Transgenic Research 11: 587-595.

Christen, U., and von Herrath, M. G. (2002)

Apoptosis of autoreactive CD8 lymphocytes as a potential mechanism for the abrogation of type 1 diabetes by islet-specific TNF-a expression at a time when the autoimmune process is already ongoing.  Ann. N. Y. Acad. Sci. 958: 166-169.

McGavern, D., Christen, U., and Oldstone, M. B. A. (2002)

Molecular anatomy of antigen-specific CD8+ T cell engagement and synapse formation in vivo.

Nat. Immunol. 3: 918-925.


Hintermann, E., Haake, S.K., Christen, U., Sharabi, A., and Quaranta, V. (2002)

Discrete proteolysis of focal contact and adherens junction components in Porphyromonas gingivalis-infected oral keratinocytes: a strategy for cell adhesion and migration disabling.

Infect. Immun. 70: 5846-5856.


Christen, U., Wolfe, T., Moehrle, U., Hughes, A. C., Rodrigo, E., Green, A., Flavell, R. A., and von Herrath, M. G. (2001)

A Dual Role for TNFa in Type 1 Diabetes: Islet Specific Expression Abrogates the Ongoing Autoimmune Process when Induced Late but not Early During Pathogenesis.

J. Immunol. 166: 7023-7032.


Hintermann, E., Bilban, M., Sharabi, A., and Quaranta, V. (2001)

Inhibitory role of a6b4-associated erbB-2 and phosphoinositide 3-kinase in keratinocyte haptotactic migration dependent on a3b1 integrin.

J. Cell Biol. 153(3): 465-478.


Liu, R., Hintermann, E., Erb, C., Tanner, H., Flammer, J., Eberle, A.N., and Haefliger I.O. (2001)

Modulation of Na/K-ATPase activity by isoproterenol and propranolol in human non-pigmented ciliary epithelial cells.

Klin. Monatsb.l Augenheilkd. 218(5): 363-5.


Gesemann, M., Litwack, E. D., Lee, K. T., Christen, U., and O’Leary, D. D. (2001)

Identification of candidate genes for controlling development of the basilar pons by differential display PCR.

Mol. Cell. Neurosci. 18: 1-12.

Hintermann, E., Tanner H., Talke-Messerer, C., Schlumberger, S., Zumsteg, U., and Eberle, A.N. (2001)

Interaction of melanin-concentrating hormone (MCH), neuropeptide E-I (NEI), neuropeptide G-E (NGE), and alpha-MSH with melanocortin and MCH receptors on mouse B16 melanoma cells.

J. Recept. Signal. Transduct. Res. 21(1): 93-116.


da Silva Correia J., Soldau K., Christen U., Tobias P.S., Ulevitch R.J. (2001)

Lipopolysaccharide is in Close Proximity to Each of the Proteins in Its Membrane Receptor Complex: Transfer from CD14 to TLR4 and MD-2.

J. Biol. Chem. 276: 21129-21135.


Von Herrath, M. G., Oldstone, M. B. A., Homann, D., and Christen, U. (2001)

Is Activation of Autoreactive Lymphocytes always Detrimental? Viral Infections and Regulatory Circuits in Autoimmunity.

Curr. Dir. Autoimm. 4: 91-122.


Christen, U., Wolfe, T., and von Herrath, M. G. (2001)

How viral infections and/or inflammation can emhance as well as abrogate autoimmunity: A double edged sword.

Recent Res. Devel. Virol. 3: 325-339.

Hintermann, E., Erb, C., Talke-Messerer, C., Liu, R., Tanner, H., Flammer, J., and Eberle, A.N. (2001)

Expression of the melanin-concentrating hormone receptor in porcine and human ciliary epithelial cells.

Invest. Ophthalmol. Vis. Sci. 42(1): 206-9.