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Publications III (2011-present)  -  Publications II (2001-2010)   -   Publications I (1991-2000)


Christen, U. (2000)

Cost of institute was small change for Roche.

Nature 406: 455.


Seewaldt, S., Thomas, H. E., Ejrnaes, M., Christen, U., Wolfe, T., Rodrigo, E., Coon, B., Michelsen, B., Kay, T. W. H., and von Herrath, M. G. (2000)

Virus-induced autoimmune diabetes: Most b-cells die through inflammatory cytokines and not perforin from autoreactive (anti-viral) cytotoxic T-lymphocytes.

Diabetes 49: 1801-1809.


Bot, A., Holz, A., Christen, U., Wolfe, T., Tenmann, A., Flavell, R. A., and von Herrath, M. G. (2000)

Local IL-4 expression in the lung reduces pulmonary influenza-virus-specific secondary cytotoxic T cell responses.

Virology 269: 66-77.


Amherd, R., Hintermann, E., Walz, D., Affolter, M., and Meyer UA. (2000)

Purification, cloning, and characterization of a second arylalkylamine N-acetyltransferase from Drosophila melanogaster.

DNA Cell Biol. 19(11): 697-705.


Christen, U., Thuerkauf, R., Stevens, R., and Lesslauer, W. (1999)

Immune response to a recombinant human TNFR55-IgG1 fusion protein in rhematoid arthritis (RA) and multiple sclerosis (MS) patients: Auto-antibodies have neither neutralizing nor agonist activities.

Hum. Immunol. 60: 774-790.


Christen, U., Thuerkauf, R., and Lesslauer, W. and the Lenercept® Rheumatoid Arthritis and Multiple Sclerosis Study Groups (1998)

Antibody response to a recombinant human TNF receptor-immunoglobulin fusion protein (TNFR55-IgG1) in rheumatoid arthritis (RA) and multiple sclerosis (MS) patients.

Roche Research Report B-169’977.


Christen, U., Thuerkauf, R., and Lesslauer, W. (1998)

Binding of TNFR55-IgG1 (Tenefuse ®, Ro 45-2081) to human cells.

Roche Research Report B-169’135.


Steinmetz, M.O., Plüss, C., Christen, U., Wolpensinger, B., Lustig, A., Werner, E.R., Wachter, H., Engel, A., Aebi, U., Pfeilschifter, J. and Kammerer, R.A. (1998)

Rat GTP Cyclohydrolase I is a homodecameric protein complex containing high-affinity EF-hand-like Calcium-binding sites.

J. Mol. Biol. 279: 189-199.


Christen, U., Baudin, M., Birnböck, H., Dumont, E., Gallati, H., Lötscher, H.R., Zaug, M. and Lesslauer, W. (1996)

Preliminary report on the anti-Ro 45-2081 antibody response in rheumatoid arthritis patients of studies BK 14680 and BM 14752.

Roche Research Report B-166’394.


Gut, J., Christen, U., Frey, N., Koch, V., and Stoffler, D. (1995)

Molecular mimicry in halothane hepatitis.

Toxicology (Section Immunotoxicology) 97: 199-224.


Frey, N., Christen, U., Jenö, P., Yeaman, S.J., Shimomura, Y., Kenna, J.G., Gandolfi, A.J., Ranek, L. and Gut, J. (1995)

Protein X and the dihydrolipoamide acetyltransferase subunits of the oxoglutarate and branched chain dehydrogenase complexes molecularly mimic trifluoroacetylated proteins and are autoantigens associated with halothane hepatitis.

Chem. Res. Toxicol. 8: 736-746.


Christen, U., Quinn, J., Yeaman, S.J., Kenna, J.G., Clarke, J.B., Gandolfi, A.J. and Gut, J. (1994)

Identification of the dihydrolipoamide acetyltransferase subunit of the human pyruvate dehydrogenase complex as an autoantigen in halothane hepatitis: Molecular mimicry of CF3CO-lysine by lipoic acid.

Eur. J. Biochem. 223: 1035-1047.


Gut, J., Christen, U. and Huwyler, J. (1993)

Mechanisms of halothane toxicity: Novel insights.

Pharmac. Ther. 58: 133-155.


Christen, U., Jenö, P. and Gut, J. (1993)

Halothane metabolism: The dihydrolipoamide acetyltransferase subunit of the pyruvate dehydrogenase complex molecularly mimics trifluoroacetyl-protein adducts.

Biochemistry 32: 1492-1499.


Huwyler, J., Aeschlimann, D., Christen, U. and Gut, J (1992)

The kidney as a novel tissue for protein adduct formation associated with metabolism of halothane and the candidate chlorofluorocarbon replacement 2,2-dichloro-1,1,1-trifluoroethane.

Eur. J. Biochem. 207: 229-238.


Gut, J., Christen, U., Huwyler, J., Bürgin, M. and Kenna, J.G. (1992)

Molecular mimicry of trifluoroacetylated human liver protein adducts by constitutive proteins and immunochemical evidence for its impairment in halothane hepatitis.

Eur. J. Biochem. 210: 569-576.


Christen, U., Bürgin, M. and Gut, J. (1991)

Halothane metabolism: Immunochemical evidence for molecular mimicry of trifluoroacetylated liver protein adducts by constitutive polypeptides.

Mol. Pharmacol. 40: 390-400.


Christen, U., Bürgin, M. and Gut, J. (1991)

Halothane metabolism: Kupffer cells carry and partially process trifluoroacetylated protein adducts.

Biochem. Biophys. Res. Commun. 175/1: 256-262.